Research Papers

Gut Microbiota and Fatigue: A Study of the Link Between Microbial Dysbiosis and Chronic Fatigue

Symptoms​

• Published: 2023

• Source: Journal of Clinical Medicine

• Focus: Investigating the connection between gut microbiota composition and general fatigue in individuals with chronic fatigue symptoms.

• Study Design: Cross-sectional study with 150 participants (75 individuals reporting chronic fatigue symptoms, 75 healthy controls).

• Findings: The study found that individuals with chronic fatigue exhibited altered gut microbiota, specifically a reduction in commensal and keystone bacteria.

 

The Role of Gut Dysbiosis in Fatigue in Patients with Fibromyalgia: A Pilot Study​

• Published: 2021

• Source: Frontiers in Nutrition

• Focus: Examining the link between gut dysbiosis and fatigue in fibromyalgia patients.

• Study Design: Case-control study with 60 participants (30 fibromyalgia patients with fatigue and 30 healthy controls).

• Findings: Fibromyalgia patients with fatigue exhibited a marked decrease in beneficial gut bacteria, particularly those involved in anti-inflammatory pathways.

 

 

Deficient Butyrate-Producing Capacity in the Gut Microbiome of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Is Associated with Fatigue Symptoms​

• Published: 2021

• Source: medRxiv (preprint)

• Focus: Investigated the gut microbiome's butyrate-producing capacity in ME/CFS patients and its association with fatigue severity.

• Study Design: Case-control study involving 106 ME/CFS patients and 91 healthy controls across the United States.

• Findings: ME/CFS patients exhibited decreased relative abundance and quantity of butyrate-producing bacteria. This deficiency correlated with increased fatigue severity.

 

Gut Microbiota and Chronic Fatigue Syndrome: A Systematic Review of Human Studies"​

• Published: 2020

• Source: Microorganisms

• Focus: Reviewing studies on gut microbiota changes in patients with chronic fatigue syndrome (CFS) and their possible relationship with fatigue.

• Study Design: Systematic review of 12 studies involving human participants with chronic fatigue.

• Findings: Most studies indicated a significant reduction in microbiota diversity in CFS patients, particularly a decrease in butyrate-producing bacteria, which may contribute to the fatigue symptoms.

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Impact of Probiotic Supplementation on General Fatigue in Older Adults: A Double-Blind, Randomized Controlled Trial​

• Published: 2019

• Source: Journal of the American Geriatrics Society

• Focus: Investigating whether probiotics can improve energy levels and reduce fatigue in older adults.

• Study Design: Double-blind, placebo-controlled trial with 80 participants aged 60 and above over 12 weeks.

• Findings: Targeted probiotic supplementation significantly reduced fatigue and improved overall energy levels in participants, with changes in gut microbiota composition observed.​​​​​​​​​