Hormone Metabolites

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Analysis of Sex Hormones​

Hormones Measured:

• Estrogens: Estrone (E1), Estradiol (E2), Estriol (E3), and their metabolites (2-OH, 4-OH, and 16-OH).

• Progesterone: Includes metabolites like β-pregnanediol and α-pregnanediol.

• Testosterone: Free testosterone and metabolites like 5α-DHT and androsterone.

Benefits:

• Identifies estrogen dominance, low progesterone, or androgen imbalances contributing to PMS, heavy periods, infertility, PCOS, or peri/menopausal symptoms.

• Provides insights into androgen-related issues like hair loss, acne or low libido.

• For men the DUTCH test provides a detailed analysis of testosterone and its metabolites, helping to understand androgen levels. Low testosterone can contribute to fatigue, reduced muscle mass, decreased libido, and mood issues.

• It measures estradiol levels in men and other estrogen metabolites, which are crucial for understanding the risk of estrogen dominance, especially in men with symptoms like weight gain, fatigue, or gynecomastia (enlarged breast tissue).​

 

Cortisol and Adrenal Function​

Hormones Measured:

• Cortisol, cortisone, and their diurnal patterns (free and metabolised cortisol).

Benefits:

• Evaluates stress response by measuring cortisol rhythm throughout the day.

• Detects adrenal concerns, like fatigue, HPA axis dysregulation, or the impact of chronic stress.

• Helps in managing fatigue, insomnia and anxiety.

 

Melatonin for Sleep and Circadian Rhythm​

Hormone Measured:

• 6-Hydroxy-Melatonin-Sulfate (a melatonin metabolite).

Benefits:

• Evaluates melatonin production for sleep-wake cycles and circadian rhythm health.

• Guides interventions for insomnia or poor quality sleep.

 

Androgen Pathways and Metabolism

Hormones and Metabolites Measured:

• DHEA-S (dehydroepiandrosterone sulphate), androstenedione, testosterone, 5α-DHT, androsterone, and etiocholanolone.

Benefits:

• Assesses androgen metabolism via the 5α-reductase and 5β-reductase pathways, helping to address issues like PCOS, excessive hair growth, or thinning hair.

• Reveals patterns contributing to aggressive or passive androgen activity which could impact the health of the prostate.

 

Estrogen Detoxification Pathways

Estrogen Metabolites Measured:

• 2-OH ("protective"), 4-OH ("potentially damaging"), and 16-OH ("pro-growth").

Benefits:

• Identifies how well estrogen is being detoxified via Phase I and Phase II liver pathways.

• Highlights risks for estrogen-related conditions like endometriosis, fibroids and  estrogen-dominance.

• Guides interventions to optimise detoxification and liver health using nutrition or supplementation.

 

Neurotransmitter and Brain Health Insights

Metabolites Measured:

• HVA (homovanillic acid) and VMA (vanillylmandelic acid) for dopamine and adrenalin/noradrenalin.​

Benefits:

• Evaluates how well the body is metabolising key neurotransmitters, such as dopamine as well as evaluating stress management.

• Identifies imbalances that may contribute to mood disorders, including anxiety, depression, irritability, or low motivation, memory and concentration.

• Provides insights for optimising mental health through targeted nutrient support or lifestyle changes.

 

Oxidative Stress Marker

Marker Measured:

• 8-Hydroxy-2-deoxyguanosine (8-OHdG).

Benefits:

• Measures DNA oxidative stress and potential cellular stress.

• Helps guide antioxidant support to reduce inflammation and improve long-term health.​

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Methylation Activity

Marker Measured:

• Methoxyestrogens (key in Phase II detoxification).

Benefits:

• Evaluates methylation efficiency for estrogen clearance.

• Supports personalised strategies to improve detoxification and reduce risks associated with poor methylation.

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DUTCH Testing: From £259.00

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